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4 Dead From Tainted Steroid Injections

26 Cases, Hundreds of Possible Infections in Outbreak of Rare Fungal Meningitis

Oct. 3, 2012 — Four people have died in an outbreak of a rare fungal meningitis linked to contaminated spinal steroid injections.

So far there are 26 known cases in five states: Tennessee (18 cases, two deaths), North Carolina (one case, no deaths), Florida (two cases, no deaths), Virginia (three cases, one death), and Maryland (two cases, one death).

“New cases are nearly certain to be identified,” Tennessee Health Commissioner John J. Dreyzehner, MD, MPH, stated this day in a news teleconference.

The infections were traced to steroid injections (methylprednisolone acetate) made by a single compounding pharmacy: The New England Compounding Center (NECC).

“FDA is working with several say health departments and is still investigating the scope and cause of the outbreak of fungal meningitis,” FDA spokeswoman Erica Jefferson tells WebMD.

One Sept. 26, the NECC recalled three suspect lots of the medication. The action was not made public, but clinics that ordered the steroid were notified.

Tainted Steroids Given to Hundreds

The first of the three suspect lots of medication were given to 737 patients in Tennessee alone. Since then, two more lots of the steroid have been recalled. One of the Tennessee clinics had 2,000 vials of the tainted medication, thought to be the largest single supply in the U.S.

People getting the calls are being told to be on the lookout for the gradual onset of fungal meningitis symptoms:

Headache, especially one that worsens Nausea, vomiting Sensitivity to light Dizziness Fever Stiff neck Slurred speech Unsteady gait Weakness Infrequent urination Changes in mental status and confusion

Only patients who got spinal injections of the tainted medication since July 1 are at risk. Those infected in this way can’t spread the infection to other people. Fortunately, the vast majority of patients who received the injections have shown no symptoms.

“Some patients who have been hospitalized are doing better, but some are very seriously ill and may die,” states David Reagan, MD, PhD, chief medical officer of the Tennessee Department of Health. “All patients who may possibly have been infected should seek help early on.”

The contaminant in the steroid shots is a fungus called Aspergillus fumigatus. Unfortunately, there is no easy treatment for this kind of fungal meningitis, states William Schaffner, MD, immediate past president of the National Foundation for Infectious Diseases.

“These are serious infections,” Schaffner says. “We have only a limited number of antifungal agents. They have efficacy, but are not perfect. Two of our patients already have succumbed. The therapy is not straightforward, and some of these agents have very serious side effects.”

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Submited at Thursday, October 4th, 2012 at 12:15 am on Uncategorized by admin
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