High risk of colorectal, endometrial and Lynch syndrome cancers for MSH6 mutation carriers

People carrying the germ-line MSH6 mutation are at high risk by age 80 years for colorectal and endometrial cancers and any cancer associated with Lynch syndrome, according to a new study published online December 22 in the Journal of the National Cancer Institute.

It is known that mutations in MSH6 account for 10%-20% of Lynch syndrome, which causes colorectal and other cancers, but less is know about the cumulative cancer risks for mutation carriers.

In this study, members of the Colon Cancer Family Registry, a National Institutes of Health-funded consortium, and colleagues identified 113 families of MSH6 mutation carriers from five countries who were identified through family cancer clinics and population-based cancer registries. Mutation status, sex, age, and histories of cancer, polypectomy, and hysterectomy were sought from 3,104 of their relatives.

The researchers determined precise estimates of both absolute and relative cancer risks for people who carry the mutation. The estimated cumulative risks to ages 70 and 80 years, respectively, were 22% and 44% for colorectal cancer for men and 10% and 20% for women. For endometrial cancer, risks were 26% and 44% for women. And for any cancer associated with Lynch syndrome, the risks were 24% and 47% for men and 40% and 65% for women. Compared with incidence for the general population, MSH6 mutation carriers had an eight-fold increased incidence of colorectal cancer. Women who were MSH6 mutation carriers had a 26-fold increased incidence of endometrial cancer and a six-fold increased incidence of other cancers associated with Lynch syndrome.

“These results demonstrate that the elevated risks for cancers in MSH6 mutation carriers differ by sex of the carrier and continue into older age,” the authors write.

###

Contact: Noralane Lindor, Mayo Foundation, nlindor@mayo.edu

Note to Reporters:

The Journal of the National Cancer Institute is published by Oxford University Press and is not affiliated with the National Cancer Institute. Attribution to the Journal of the National Cancer Institute is requested in all news coverage.

Visit JNCI online at http://jnci.oxfordjournals.org and the JNCI press room at http://www.oxfordjournals.org/our_journals/jnci/press_room.html

For the latest cancer news and studies, follow us on Twitter @JNCI_Now

source : www.eurekalert.org

Related News:

• Greater Infection Risk with Staples in Hip Surgery (CME/CE)
• SGO: No Lung CA Risk Seen with Estrogen (CME/CE)
• Genetic variations influence statin efficacy for lowering colon cancer risk
• Heart transplant patients face greater risk of skin cancer
• Risk Factor Analysis In A Contemporary Cystectomy Cohort Using Standardized Reporting Methodology And Adverse Event Criteria
• Greater Infection Risk with Staples in Hip Surgery
• SIR: ABI Flags Those Not Otherwise at Risk for CVD
• Broken Hip Increases 10-Year Death Risk
• The Body’s Anticipation Of A Meal Can Be A Diabetes Risk Factor
• No Increased Risk of Death with ‘The Pill’