Loss of tumor-suppressor and DNA-maintenance proteins causes tissue demise

(University of Pennsylvania School of Medicine) A study published in the October issue of Nature Genetics demonstrates that loss of the tumor-suppressor protein p53, coupled with elimination of the DNA-maintenance protein ATR, severely disrupts tissue maintenance in mice. As a result, tissues deteriorate rapidly, which is generally fatal in these animals. In addition, the study provides supportive evidence for the use of inhibitors of ATR in cancer therapy.

source : www.eurekalert.org

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