Scientists discover key event in prostate cancer progression

(Ohio State University Medical Center) Researchers at the Ohio State University Comprehensive Cancer Center and Dana-Farber Cancer Institute have discovered how hormone-dependent prostate cancer advances to the incurable hormone-independent disease state. The study shows that in androgen-independent prostate cancer, androgen receptors are reprogrammed to regulate genes involved in a later phase of cell division. A small epigenetic change in a gene called UBE2C is responsible for this reprogramming. Increased expression of that gene correlated with progression to the hormone-independent phase.

source : www.eurekalert.org

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Submited at Thursday, July 23rd, 2009 at 12:01 pm on Cancer and Oncology by sofia
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