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High-Dose Simvastatin Linked to Increased Myopathy

High-Dose Simvastatin Linked to Increased Myopathy

WASHINGTON — Increasing simvastatin (Zocor) to 80 mg a day increases the risk of myopathy, including rhabdomyolysis, according to an FDA safety warning.

Increasing the simvastatin dose to 80 ...

ACC: STEMI Patients Helped by Aspirating the Clot

ATLANTA — Rheolytic thrombectomy before stenting improved outcomes over stenting alone among patients with ST-elevation myocardial infarction (STEMI), a multicenter, randomized trial showed.
Removal of the thrombus with the ...

ACC: Renin Inhibitor Fails to Improve Post-MI Outcomes

ATLANTA — When added to optimal medical therapy, aliskiren (Tekturna), a direct renin inhibitor, did not improve outcomes for patients who had had a myocardial infarction accompanied by ...

ACC: Both Sides See Red During Industry Funding Debate

ATLANTA — A red dress jauntily displayed on cans of Diet Coke has become the latest symbol in the on-going debate about pharmaceutical company support of research or ...

ACC: Triglycerides Decreased with Rosuvastatin Therapy

CME Information
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ED May Predict Cardiac Events, Earlier Death

Patients with erectile dysfunction (ED) who were treated with telmisartan, ramipril, or both were at greater risk for cardiovascular events than other patients on the same medications, researchers found.
In men ...

ACC: FDA Announces Review of ACCORD Data

ATLANTA — The FDA stated it will conduct a full review of findings from a study which concluded that neither aggressive lipid-lowering therapy nor tight blood pressure control reduced cardiovascular ...

ACC: Clopidogrel Black Box Likely to Have Immediate Clinical Impact

ATLANTA — The FDA’s decision to add a black box warning to the label of clopidogrel (Plavix) came without warning to physicians attending the American College of Cardiology meeting here. ...

Boxed Warning Added to Clopidogrel Label, Testing Suggested

Prescribing information for clopidogrel (Plavix) will now include a boxed warning that the drug can be less effective in poor metabolizers, the FDA indicated.

The new warning suggests that many if ...

ACC: Devices May Trump Drugs in Atlanta

ATLANTA — The buzz preceding Sunday’s opening of the annual American College of Cardiology meeting is that a bumper crop of late-breaking trials is likely to yield tiny ...

Docs Often Miss Lipid Targets, More So with Women (CME/CE)

Primary care doctors may only treat to recommended cholesterol targets about half the time, and even less when the patient is a woman, a survey of German doctors showed.
Researchers asked ...

Novel Thyroid Hormone Analogue Aids Lipid Lowering (CME/CE)

An experimental agent that mimics thyroid hormone in the liver enhanced the lipid-lowering effect of statins in a randomized controlled trial.
The thyroid hormone analogue, eprotirome, reduced LDL cholesterol by up ...

ASCO GU: BP Reveals Hit or Miss for Targeted Tx

SAN FRANCISCO — Early response to preoperative targeted therapy for metastatic renal cell carcinoma may indicate efficacy, while treatment-induced hypertension may be another marker after surgery, researchers reported ...

Study Supports Conventional CPR for Children in Arrest

Children who have out-of-hospital cardiac arrest have a better chance of a favorable neurologic outcome with bystander cardiopulmonary resuscitation (CPR), data from a massive Japanese study showed.
Bystander CPR doubled the ...

HbA1c More Predictive than Glucose

Glycated hemoglobin (HbA1c) outperformed blood glucose as a predictor of cardiovascular disease (CVD) and all-cause mortality and had similar predictive accuracy for diabetes, data from a massive cohort study showed.
As ...

CCDEP: Coffee Not Linked to Serious Arrhythmias (CME/CE, with audio)

SAN FRANCISCO — Contrary to conventional thinking, drinking lots of coffee appears to be associated with a lower risk of hospitalization for an arrhythmia, researchers found.
In a long-term ...

No Benefit from Aspirin in Low ABI

Prophylactic aspirin had no effect on the risk of vascular events in patients with a low ankle-brachial index (ABI) but no evidence of cardiovascular disease, data from a randomized clinical ...