Delirium, an Adverse Outcome Faced by People With Alzheimer’s

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Led by researchers at Harvard Medical School affiliates Hebrew SeniorLife and Beth Israel Deaconess Medical Center (BIDMC), the study appears in the June 19 online issue of the Annals of Internal Medicine.”Evidence has shown that older patients with Alzheimer’s disease [AD] are much more likely to be hospitalized than other older patients,” states lead author Tamara Fong, MD, PhD, assistant scientist in the Aging Brain Center, Institute for Aging Research at Hebrew SeniorLife and Assistant Professor of Neurology at BIDMC.

“Because our previous research had found that AD patients experienced a three times faster decline in mental function if they had experienced delirium, we wanted to determine if AD patients who are hospitalized are at greater risk for poor outcomes than AD patients who are not hospitalized, and if there is any additive negative outcome when hospitalized AD patients develop delirium.”The researchers, therefore, analyzed the records of 771 patients over age 65 who were analyzed between 1991 and 2006 at the Massachusetts Alzheimer’s Disease Registry (MADRC), a clinical registry based at Massachusetts General Hospital. “We looked at patients with and without hospitalizations who were seen at least three times in the MADRC during the study interval period,” states Fong.

“Going forward, we plan to conduct formal studies to determine if these types of interventions can help improve outcomes for this vulnerable group of patients,” she explains.Adds senior author Sharon Inouye, MD, PhD, Director of the Aging Brain Institute at HSL, Harvard Medical School Professor of Medicine at BIDMC, “Our confirmation that hospitalization and delirium play important roles in adverse outcomes may ultimately influence care and management of patients with AD. Interventions to prevent hospitalization and hospital-associated delirium may be appropriate for all patients with AD. The cost savings to Medicare would be far greater than the amount from current treatment options for AD.”

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Submited at Tuesday, June 19th, 2012 at 11:00 am on Uncategorized by ethan
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