ScienceDaily (Oct. 26, 2012) In 2010 around 300,000 babies were born with sickle cell anemia, a serious blood disorder which can be fatal if untreated, and 5.5 million newborns inherited the sickle cell gene, a new study suggests.
Whilst the 5.5 million who only inherit the gene will usually not present any clinical complications, these individuals could still pass this gene on to their offspring and give birth to babies suffering from sickle cell anemia. Accurate estimates of the numbers and geographical distribution of those affected is vital for effective prevention and treatment policies to be put in place.
The research by the Malaria Atlas Project (MAP), a multinational team of researchers funded mainly by the Wellcome Trust, maps the geographical contemporary distribution of sickle haemoglobin — a genetic disorder causing sickle cell anemia. It also estimates the number of newborns affected by this condition.
Historically, the sickle cell gene (haemoglobin S or HbS) was common in people of African, Mediterranean and Indian origin but, following human migrations, it is now much more widespread. The MAP team’s estimates suggest that about half of the affected newborns are born in Nigeria, the Democratic Republic of the Congo, and India, but important uncertainties remain in massive parts of these countries due to a lack of data.A report of the research is published October 25 in The Lancet.
Dr Fred Piel from Oxford University’s Department of Zoology, who led the research, said: ‘Sickle cell disease has now been studied intensively for more than a hundred years but our knowledge about its current distribution and burden is really poor. Our aim was to use available evidence-based epidemiological data from the literature combined with modern mapping and modelling methods to come up with the ideal maps and estimates. In the future, we hope that accessing additional data, including from national screening programmes, would help further refine these results.’
The study provides the first rigorous assessment of the contemporary distribution of this disorder and uses state-of-the-art methodology to estimate the number of newborns affected globally, regionally and nationally. The team was inspired by work conducted by Frank B Livingstone in the 1970s and 80s. In spite of its age, his global database on inherited blood disorder frequencies still represents a unique resource. There is growing awareness about the burden of genetic blood disorders — sickle cell disease in particular — and it is crucial for public health policy makers to access evidence-based quantitative epidemiological data allowing the assessment of the current situation and to measure changes in the future. The data will be released in open access on the MAP website.
Professor Sir David Weatherall, who has shared his unique expertise in the field and provided exceptional support to the project, said: ‘The inherited haemoglobin disorders, notably sickle cell disease and the different forms of thalassaemia, are by far the commonest monogenic diseases and the vast majority of births affected occur in low- or middle-income countries. Previous work suggested that their distribution varied considerably even within short geographical distances and data regarding their true frequency is extremely difficult to obtain.
‘Hitherto, they have been largely ignored by the international health community and it is absolutely vital that better information is obtained regarding their true frequency so that their control and better management can be achieved, particularly in the developing countries where they are so common. The impressive work described in this paper provides an invaluable base for future work of this kind.’
Share this story on Facebook, Twitter, and Google:
Other social bookmarking and sharing tools:
The above story is reprinted from materials provided by University of Oxford.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
- Computational apolipoprotein estimates ‘reliable’ for CV risk
- Anemia Triples Death Risk After Stroke
- FDA and CDC Clear Enfamil Infant Formula
Submited at Friday, October 26th, 2012 at 4:15 pm on Uncategorized by Alina
Comment RSS 2.0 - leave a comment - trackback